Department of
Anesthesiology and Perioperative Medicine

Tang Lab

Research Overview (publications)

Dr. Tang’s laboratory has focused on two related research areas. One is to determine the structures and dynamics of neurotransmitter-gated ion channels, which play a central role in neuron signaling and are targets of therapeutics. Another is to understand channel protein interactions with low-affinity drugs, particularly general anesthetics and alcohols. Various biophysical tools, including high-resolution nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, as well as large-scale molecular dynamic simulations, have been utilized to tackle various biomedical and neuroscience questions.

Projects

  • Structural basis of neurosteroid anesthetic action on GABAA receptors
  • Recent progress on the molecular pharmacology of propofol

News/Media Appearances

Lab Members

Principal InvestigatorPei Tang, PhD

Visiting Scientists and Research Faculty
Palaniappa Arjunan, PhD
Vasyl Bondarenko, PhD
Qiang "Charles" Chen, PhD
Tommy Tillman, PhD

Graduate Students
Marta Wells (Computational & Systems Biology)

Undergraduate Researchers
Nathan Reinert

Lab Contact Info

Pei Tang, PhD

Office Phone: 412-383-9798

Lab Phones: 412-648-2945
                     412-648-9137
                     412-648-9024

Fax:
412-648-8998