Department of
Anesthesiology and Perioperative Medicine

Basic Research

Our current basic research focuses on topics such as mechanisms of anesthesia, pain, and neuronal injury and protection; alcoholism; and ventilator-induced lung injury.

 

embryo cytoplasmic microinjection

Alcohol Neurobiology and Genetic Engineering

Gregg Homanics, PhD
The Homanics Lab is interested in understanding the effects of alcohol on the body so that safe, effective treatments for alcohol use disorder can be developed.

slowing an over-excited heart rate with epidural anesthesia

Cardiac Anesthesiology

Aman Mahajan, MD, PhD, MBA
The Mahajan Lab’s primary research focus is spinal neural modulation of cardiac electrophysiology and the assessment of cardiac function in heart failure.

Kimberly Howard-Quijano, MD, MS
Dr. Howard-Quijano received a K08 from the NIH NHLBI for five years to further her work in the investigation of Spinal Neuraxial Modulation of Ventricular Arrhythmias – Mechanisms and Treatments

images from the Xu Lab

Mechanisms of General Anesthesia, Pain, and Neuronal Injury and Protection

Pei Tang, PhD
Research in the Tang Lab focuses on the action of low-affinity drugs, such as general anesthetics and alcohols, on the neurotransmitter-gated receptor channels.

Bradley K. Taylor, PhD
Dr. Taylor's laboratory investigates the mechanisms through which inflammation or injury produces changes in the peripheral nerves, spinal cord, and brain, leading to a transition from acute pain to chronic pain. 

Yan Xu, PhD
The Xu Lab research team is one of the leading groups in the world to combine high-resolution and solid-state NMR techniques to solve membrane protein structures at atomic resolution.

neurons

Neuroscience

Tomas Drabek, MD
Dr. Drabek's research carried out at the Safar Center for Resuscitation Research is focused on hemorrhagic shock and resuscitation from both traumatic and non-traumatic cardiac arrest caused by asphyxia or ventricular fibrillation. 

Marsha Ritter Jones, MD, PhD
Dr. Ritter Jones is studying how skin, sensory nerves, and the immune system communicate to maintain the protective barrier of the body and respond to inflammatory challenges such as autoimmune diseases and infections.

two-hit model: MV+CLP-sepsis

Ventilator-Induced Lung Injury (VILI)

Li-Ming Zhang, MD
Dr. Zhang’s current research focuses on identifying the susceptibility genes of VILI via an unbiased genome-wide association study in inbred mice and to evaluate its relevant functional significance.