Dr. Cole has performed research in neuroscience at the molecular, synaptic, cellular, circuit, and behavioral levels. In his undergraduate research at the University of Central Florida, he studied Schwann cell motility dynamics in a mouse model of NF2 and developed and utilized a novel imaging modality in the laboratory of Dr. Cristina Fernandez-Valle. He then entered the Medical Scientist Training Program at the University of Maryland School of Medicine, where he completed a PhD in Neuroscience in the laboratory of Dr. Scott Thompson. Dr. Cole's thesis work utilized patch clamp electrophysiology, optogenetics, and behavioral studies to identify a neural circuit connecting ventral hippocampal activity to regulation of the HPA axis and the neuroendocrine stress response. He hopes to apply these experiences to the study of anesthetic mechanisms of action and the neural circuits involved in anesthetic induction and emergence.
- MD, University of Maryland School of Medicine
- PhD, Neuroscience, University of Maryland School of Medicine
- BS, Molecular and Microbiology and minor certificate in Cognitive Sciences, University of Central Florida
Education & Training
Cole AB, Montgomery K, Bale TL, Thompson SM. (2022). What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons. Neurobiology of stress, 20, 100473. https://doi.org/10.1016/j.ynstr.2022.100473
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson, SM. (2021). Harnessing psilocybin: Antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice. Proceedings of the National Academy of Sciences, 118(17), 1–7. https://doi.org/10.1073/pnas.2022489118
Morrison KE, Cole AB, Thompson S.M, Bale TL. (2019). Brexanolone for the treatment of patients with postpartum depression. Drugs of Today, 55(9), 537–544. https://doi.org/10.1358/dot.2018.55.9.3040864
Morrison KE, Cole AB, Kane PJ, Meadows VE, Thompson SM, Bale TL. (2020). Pubertal adversity alters chromatin dynamics and stress circuitry in the pregnant brain. Neuropsychopharmacology, 45(8), 1263–1271. https://doi.org/10.1038/s41386-020-0634-y
Wenzel JM, Oleson EB, Gove WN, Cole AB, Gyawali U, Dantrassy HM, Cheer JF. (2018). Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Current Biology, 28(9), 1392-1404.e5.https://doi.org/10.1016/j.cub.2018.03.037