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REGAIN Trial Update Published with Editorial

"Headshot of Doctor Luke next to a screenshot of the title and contributors to the clinical trial"

Annals of Internal Medicine published an update on the REGAIN trial (“Regional Versus General Anesthesia for Promoting Independence After Hip Fracture”) by the study’s investigators, who include Charles B. Luke, MD, MBA, FASAM. The journal also published an editorial featuring the study. The investigators’ initial findings were published in The New England Journal of Medicine in October 2021. Other REGAIN study collaborators from our department include Jacques E. Chelly, MD, PhD, MBA (site PI)Shiv K. Goel, MDWende A. Goncz, DO, MMMTouichi Kawabe, MDSharad K. Khetarpal, MBBS, MD, FFARCSIAmy Monroe, MPH, MBA; and Vladislav I. Shick, MD.

  • Neuman MD, Feng R, Ellenberg SS, Sieber F, Sessler DI, Magaziner J, Elkassabany N, Schwenk ES, Dillane D, Marcantonio ER, Menio D, Ayad S, Hassan M, Stone T, Papp S, Donegan D, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Tierney A, Gaskins LJ, Horan AD, Brown T, Dattilo J, Carson JL; REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture) Investigators*. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial. Ann Intern Med. 2022 Jun 14. doi: 10.7326/M22-0320. Epub ahead of print. PMID: 35696684. PubMed link | Full text link
  • Arriaga AF, Bader AM. EDITORIAL: Severe Pain After Hip Fracture Repair in Older Adults: Challenging a Dominant Narrative. Ann Intern Med. 2022 Jun 14. doi: 10.7326/M22-1391. Epub ahead of print. PMID: 35696690. PubMed link | Full text link

The work was also featured in Pain Medicine News and Anesthesiology News.