Education & Training
- Charles University, Prague, Czechoslovakia, MD
- Charles University, Prague, Czech Republic, PhD
Dr. Drabek's publications can be reviewed through the National Library of Medicine's publication database.
Research, clinical, and/or academic interests
Dr. Drabek's research carried out at the Safar Center for Resuscitation Research is focused on hemorrhagic shock and resuscitation from both traumatic and non-traumatic cardiac arrest (CA). The main focus is exsanguination CA (ExCA), a relatively unexplored form of CA. Resuscitation of ExCA victims with the conventional cardiopulmonary resuscitation (CPR) technique has a poor prognosis because of a volume-depleted and trauma-disrupted circulatory system. However, in an appropriate setting, many of those injuries would be repairable. His team has developed a breakthrough concept of emergency preservation and resuscitation (EPR) that uses cold aortic flush to induce deep hypothermia, thus decreasing metabolic demands to preserve the organs, and buying time for transport and damage-control surgery. Delayed resuscitation is then achieved via cardiopulmonary bypass (CPB). They developed a rat EPR model to elucidate mechanisms associated with ischemia-reperfusion injury, and to test novel therapies. Extended CA durations showed significant regional and temporal differences in neuronal death and neuroinflammation.
Current work is focused on neuroinflammation-induced reperfusion injury and blocking the deleterious pathways with novel gene-based therapies. Dr. Drabek collaborates with the Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon University where cerebral blood flow is assessed with MRI. The use of a rat CPB model also has direct relevance to cardiac anesthesia, including deep hypothermic circulatory arrest.